Pertiwi K, Küpers LK, de Goede J, et al. - Findings from a cohort of Dutch patients with prior myocardial infarction revealed a consistent association of higher dietary and circulating eicosapentaenoic and docosahexaenoic acid (EPA+DHA) and fish intake with a lower coronary heart disease (CHD) mortality risk.

• Population‐based studies have demonstrated a lower risk of fatal CHD in relation to habitual consumption of long‐chain omega‐3 fatty acids, especially EPA+DHA from fish.

• Data were obtained from 4,067 Dutch patients with prior myocardial infarction aged 60 to 80 years (79% men, 86% on statins) (Alpha Omega Cohort), to examine the links of dietary and circulating EPA+DHA and alpha‐linolenic acid, a plant‐derived omega‐3 fatty acids, with long‐term death risk post-myocardial infarction.

• Significant inverse association between dietary intake of EPA+DHA and CHD mortality was found (hazard ratio HR, 0.69 for >200 vs ≤50 mg/d; HR, 0.92 per 100 mg/d).

• For fish intake, similar results were achieved (HR _CHD , 0.74 for >40 vs ≤5 g/d).

• Circulating EPA+DHA was found to be inversely related to CHD mortality (HR, 0.71 for >2.52% vs ≤1.29%; 0.85 per 1‐SD) and also to cardiovascular diseases and all‐cause death.

• No significant link was found between dietary and circulating alpha‐linolenic acid and mortality endpoints.