Diaphragmatic muscle thickness and diaphragmatic function are reduced in patients with systemic lupus erythematosus compared to those with primary Sjögren’s syndrome
Lupus May 01, 2020
Satış H, Cindil E, Salman RB, et al. - This study was attempted to assess if SLE individuals have impairment in their diaphragmatic muscle thickness and function with respect to another connective-tissue disease: primary Sjögren’s syndrome (pSS). Researchers enrolled individuals, diagnosed with SLE who were in remission or who had minimal disease activity and had at least one year of follow-up. They performed ultrasonographic assessment of the diaphragmatic muscle by an experienced independent sonographer at three time points, diaphragmatic thickness during deep and quiet inspiration and maximum expiration being assessed. They analyzed diaphragmatic muscle function with maximum expiratory pressure and maximum inspiratory pressure. Analysis included with a sum of 115 individuals (n = 39 SLE; n = 76 pSS). Compared with those with pSS, SLE individuals had decreased diaphragmatic muscle thickness, which was correlated with impaired functional tests. Further prospective studies are required to assess whether structural and functional impairments in diaphragmatic muscle play a role in an elevated risk of pulmonary infections and SLS in individuals with SLE.
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