Takako M, et al. - A noncomparative study was conducted to ascertain whether a fever pattern is related to a diagnosis of autoinflammatory disease (AID) in pediatric- and adult-onset individuals. Between 2005 and 2016, the final diagnosis of individuals suspected to have AID was evaluated against gene polymorphisms known to be responsible for AID, clinical manifestations, and fever patterns, in the institute. Researchers included a total of 210 individuals (135 pediatric-onset and 75 adult-onset) and that were divided into the following 3 subgroups: (1) periodic fever (n = 74 and 25 for pediatric and adult-onset, respectively), (2) recurrent fever lacking a regular period (n = 47 and 41), and (3) persistent fever (n = 14 and 9). compared with adult-onset individuals, the autoinflammatory disease was more likely to be diagnosed in pediatric-onset individuals. AID was primarily distinguished in individuals with periodic fever and never diagnosed in individuals with persistent fever in both age-onset groups.