Mustafa AI, Al -refaie AM, El-Shimi OS, et al. - MicroRNAs (miRNAs) that have been studied appear to play a role in the pathogenesis of alopecia areata (AA) and may be used as possible indicators of disease activity. More research, however, is required to determine their precise role and therapeutic significance.

• The skin expression levels of miRNAs-155, 146a, and 203 were measured using reverse transcriptase-quantitative PCR (RT-qPCR) in 50 patients with patchy AA and 25 healthy controls.

• When compared with the control group, the studied patients had significantly higher levels of miRNAs-203, 146a, and 155 lesional tissue expression.

• Only the skin expression level of miRNA-146a was significantly greater in patients with numerous lesions.

• Patients with active AA, on the other hand, showed considerably higher tissue expression levels of the studied miRNAs than those with inactive disease.