Diagnostic accuracy of procalcitonin, neutrophil-to-lymphocyte ratio, and C-reactive protein in detection of bacterial infections and prediction of outcome in nonneutropenic febrile patients with lung malignancy
Journal of Oncology Aug 28, 2020
Ding S, Ma J, Song X, et al. - This retrospective clinical study was conducted to assess the value of procalcitonin (PCT), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) in differentiating infectious fever from tumor fever (TF) as well as if they can be used to evaluate outcomes in nonneutropenic lung cancer patients (NNLCPs). A total of 311 NNLCPs with bacterial infections and 277 with TF participated in this study. Significantly higher levels of inflammatory markers (PCT, CRP, white blood cells, neutrophils, and NLR) were detected in patients with bacterial infections vs in those with TF. Among patients with bacterial infections, a significantly raised PCT level was detected in those with progressive disease after radiotherapy and chemotherapy. Overall, experts concluded that PCT was better than CRP and NLR in diagnosing febrile patients with bacterial infections. Also, they suggested the utility of PCT in evaluating the clinical results and cancer progression in NNLCPs.
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