Sammel AM, et al. - Researchers conducted the Giant Cell Arteritis and PET Scan (GAPS) study in order to evaluate a newer generation positron emission tomography/computed tomography (PET/CT) of the head, neck, and chest regarding its accuracy for determining a diagnosis of giant cell arteritis (GCA). Time-of-flight PET/CT (1-mm slice thickness from the vertex to diaphragm) was performed on 64 patients with newly suspected GCA within 72 hours of starting glucocorticoids and before undergoing temporal artery biopsy (TAB). The scans were reviewed by two physicians with experience in PET in a blinded manner who then reported the scans as globally positive or negative for GCA. Outcomes suggest that PET/CT protocol has high diagnostic accuracy supporting its use as a first-line test for GCA. This test showed a negative predictive value of 98% indicating its particular utility in ruling out the condition in patients considered to be at lower risk of GCA. Over TAB, PET/CT seemed to be beneficial in identifying vasculitis mimics and aortitis.