Tuna MA, Rothwell PM., et al. - Since diagnosis of transient ischemic attacks (TIAs) can be difficult, researchers assessed the incidence, clinical features, investigation, and prognosis of non-consensus TIAs (ie, certain monosymptomatic events with sudden onset, non-progressive, focal deficits) vs classic TIAs, with short-term stroke risk categorized by delay to presentation and early antiplatelet treatment, two potentially confounding factors. They identified 2,878 patients with minor ischemic stroke (n = 1,287), classic TIA (n = 1,021), or non-consensus TIA (n = 570) between April 1, 2002, and March 31, 2018. Findings suggested that non-consensus TIA patients are at high early and long-term risk of stroke and have cardiovascular pathological findings on investigation comparable to those of classic TIA. Compared to patients with classic TIA, those with non-consensus TIA were less likely to seek medical attention on the day of the event and were more likely to have recurrent strokes before seeking attention. Seven-day stroke risk after seeking attention for non-consensus TIA was still substantially higher than the expected background risk, even after excluding such recurrent strokes, especially if the patient sought attention on the day of the index event. While stenoses in the posterior circulation were more common in non-consensus TIA, prevalence of atrial fibrillation, patent foramen ovale, and arterial stenoses at baseline were comparable for non-consensus TIA and classic TIA. Designation of non-consensus TIAs as definite cerebrovascular events will increase overall TIA diagnoses by approximately 50%.