Barman PK, et al. - Researchers gave evidence that improved myeloid cell production in T2D mice (db/db; hereafter called DB) following skin wounding possibly results from alterations in bone marrow progenitors generated during homeostasis and maintained after injury. Additionally, cells in the LSK population of DB mice are preprogrammed towards myeloid commitment at the transcriptional level, and cultured myeloid progenitors from DB mice generate more monocytes ex vivo vs their non-diabetic counterparts. Via bone marrow transfer between interleukin-1 receptor 1 (IL-1R1) KO and DB mice, it was exhibited that IL-1R1 signaling is likely, not involved in myeloid skewing in DB mice. Moreover, in vitro experiments implied that macrophage colony-stimulating factor receptor signaling is not likely involved in improved myeloid transcription factor expression in LSK cells of DB mice. Thus, myeloid lineage commitment in bone marrow may contribute to enhanced macrophage numbers seen in diabetic skin wounds, and that approaches to monitor monopoiesis during homeostasis or postwounding may enhance diabetic wound healing.