Xu R, Zhu Y, Lu Y, et al. - Researchers conducted this prospective, randomized, double-blind, single-center clinical trial to compare the influences of dexmedetomidine and midazolam on hemodynamics and recovery after partial and total laryngectomy. American Society of Anesthesiologist physical status III and IV male adults undergoing elective laryngectomy were selected and allocated randomly to obtain either dexmedetomidine (group D) or midazolam (group M). At the points of wakefulness and departure, the prevalence of no coughing was significantly higher in group D than in group M. Dexmedetomidine is an effective option compared with midazolam to attenuate coughing and hemodynamic changes with a low incidence of adverse outcomes following partial and complete laryngectomy after emergence from anesthesia.