Klag EA, Kuhlmann NA, Tramer JS, et al. - In this study, the impact of dexamethasone on pain, postoperative nausea and vomiting, and length of stay following total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (RTSA) was explored. Researchers examined a total of 112 patients who had undergone TSA or RTSA by a single surgeon for inclusion in this investigation. A prospective randomized, controlled trial was conducted to assess the impact of 10mg of dexamethasone administered within 90 minutes of surgery. For the final analysis, a total of 75 individuals were included with 32 patients (42.7%) randomized to the control group and 43 (57.3%) randomized to the dexamethasone group. This study’s findings revealed that dexamethasone reduces opioid requirements in the first 24 hours following surgery, provides improved pain control, and reduces antiemetic use following shoulder arthroplasty. According to the results, dexamethasone was found to be an important multimodal adjunct for controlling pain and postoperative nausea and vomiting following primary total shoulder arthroplasty.