Oluwagbemigun K, et al. - Researchers used latent (class) growth models to explore sex-specific trajectories of body mass index (BMI) standard deviation score (SDS) from 4 to 18 years of age in 354 males and 335 females in a sample from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study. Cardiometabolic risk markers that were highly related to BMI SDS trajectory, as well as differences in the identified cardiometabolic risk markers between pairs of trajectories, were assessed. In males and females, they identified 4 (“low-normal weight”, “mid-normal weight”, “high-normal weight”, and “overweight”) and 3 (““low-normal weight”, “mid-normal weight”, and “high-normal weight”) trajectories, respectively. A common determinant of the “high-normal weight” and “overweight” trajectories was higher maternal prepregnancy BMI, and “overweight” trajectory was associated with elevated interleukin-18 (IL-18) in late adolescence–young adulthood. Overall, the role of maternal prepregnancy BMI in overweight was emphasized and IL-18 was highlighted as a cardiometabolic signature of overweight across life.