• Profile
Close

Development of tuberculosis in cancer patients receiving immune checkpoint inhibitors

Respiratory Medicine Dec 18, 2019

Im Y, Lee J, Kim SJ, et al. - In order to gain a better understanding of tuberculosis (TB) development in cancer patients receiving immune checkpoint inhibitors (ICIs), researchers investigated 1,144 solid-cancer patients who initiated ICIs (pembrolizumab, nivolumab, or atezolizumab) between July 2014 and December 2018, to assess the development of TB in these individuals. The study sample comprised of lung cancer (n = 796, 69.6%) cases the most, followed by cases with melanoma (n = 115, 10.1%), and lymphoma (n = 85, 7.4%), with a median age of 62 years at the commencement of ICI treatment. The patients were administered ICIs for a median duration of 42 days (IQR; 18–154 days) and were observed for a median duration of 187 days (IQR; 70–342 days) following the start of ICIs. TB developed in 3 patients, two of whom were treated with nivolumab and one who received pembrolizumab. This shows that TB development is possible in cancer patients receiving ICIs. However, the small sample size did not allow experts to draw accurate conclusions regarding the role of ICIs in the development of TB. Moreover, it was unclear if the incidence of TB would be comparable with the incidence of TB in elderly cancer patients.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay