Pivodic A, Johansson H, Smith LEH, et al. - In the present study, the researchers sought to create a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity in order to safely reduce the screening of infants who did not require treatment. The Swedish National Registry for ROP provided data for DIGIROP-Screen development (DevGroup, N = 6,991), including infants born at 24–30 weeks of gestational age (GA). DIGIROP-Screen, a clinical decision support tool that uses readily available birth and ROP screening data for infants born GA 24–30 weeks in European and North American populations tested, can safely identify infants who do not require ROP screening. When compared with other models, DIGIROP-Screen had equal or higher sensitivity and specificity. DIGIROP-Screen should be validated in any new cohort, and if not, it can be modified using the same statistical approaches used in a specific clinical setting.