Thiele RH, Sarosiek BM, Modesitt SC, et al. - Whether Enhanced Recovery (ER, an altered management framework wherein a multidisciplinary team of stakeholders uses evidence-based medicine to protocolize all aspects of a surgical care to permit more rapid return of function) principles were generalizable across an institution and could be executed across a multitude of surgical disciplines with improvements in length of stay, opioid use, and cost of car, was determined herein. This analysis involved 7,774 patients in 9 distinct surgical groups including 2,155 patients in the pre-ER cohort and 5,619 in the post-ER cohort. Several significant alterations occurred in relation to introduction of an ER protocol: a decrease in length of stay in 5 of 9 specialties; decrease in opioid use in 8 specialties; no change or decrease in maximum patient-reported pain scores; and reduction or no alteration in hospital expenses in all specialties. During study span, an aggregate increase in profit was reported in relation to the ER program. Overall, it was concluded that significant improvements in patient care, opioid use, hospital capacity, and profitability within a large academic medical center can be achieved via institution-wide efforts to adopt ER.