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Developing a model for predicting venous thromboembolism in obese pregnant women in a national study

Thrombosis Research Apr 27, 2020

Ellis-Kahana J, Sparks AD, Gimovsky AC, et al. - Researchers aimed at developing a risk prediction model for venous thromboembolism (VTE) in obese pregnant women via performing a retrospective cohort analysis using the Consortium on Safe Labor (CSL) database. They identified 83,500 women for inclusion in this work; on average these women were 27.8 years old, 38.6 weeks gestation, with BMI 35.8, and cesarean delivery incidence of 35.2%. VTE event was reported in 109 women (0.13%). The final multivariable predictive model included the following factors that are independent predictors of VTE: mode of delivery, BMI, pregestational diabetes, chronic heart disease, preeclampsia, blood transfusion (intrapartum or postpartum), prenatal history of thromboembolic disorder, and postpartum maternal length of stay. The developed model is identified as a strong predictive model for distinguishing risk of VTE in obese pregnant women; this model may aid in future protocol development of obstetrical thromboprophylaxis in obese women.

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