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Determinants of the high admission blood pressure in mild-to-moderate acute intracerebral hemorrhage

Journal of Hypertension Jun 05, 2019

Wang X, et al. - Researchers performed pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials with 3,233 patients (mean age 63 years; 37% female; baseline mean SBP 179 mmHg), to identify the predictive factors of early elevation in blood pressure (BP) following spontaneous intracerebral hemorrhage (ICH). In these trials, either intensive (target SBP < 140 mmHg) or guideline-recommended (SBP < 180 mmHg) treatment was provided to patients with spontaneous ICH (<6 hours) and raised SBP (150–220 mmHg). Findings revealed an association of high admission BP of mild-to-moderate acute ICH with the autonomic nervous system activated “stress” rather than hematoma location and mass impact. High admission BP had significant positive links with history of hypertension, admission hyperglycemia at least 6.5 mmol/l, elevated heart rate, and greater neurological severity (National Institutes of Health Stroke Scale scores) with both analytic approaches.

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