Orbai AM, Perin J, Gorlier C, et al. - Researchers intended to determine if there is an association between life impact and gender in psoriatic arthritis (PsA). Study participants had comprehensive PsA evaluation: Disease Activity in PSoriatic Arthritis (DAPSA), Minimal Disease Activity (MDA), and Psoriatic Arthritis Impact of Disease (PsAID). Using t-tests or Wilcoxon tests, disease activity was compared by gender. Using hierarchical generalized linear models, the association of PsAID with gender was analyzed. Of 458 candidates 50.2% were male, mean age (SD) 53.1 (12.6) years, PsA duration 11 (8.2) years, and 51.5% receiving bDMARDs. Findings suggested an independent association of high life impact with female gender, enthesitis, comorbidities, and tender joints. At treatment target (T2T), the impact of women vs men on life was higher. The impact of life must become part of the strategies of PsA T2T.