Liu J, Tio MC, Verma A, et al. - In comparison with the general population, urinary calcium excretion is markedly lower in individuals with chronic kidney disease (CKD). The results showed that determinants of urinary calcium excretion differed between sexes and levels of CKD. Via estimated glomerular filtration rate (eGFR), significant relationships between urinary calcium excretion and adverse clinical events were substantially confounded.

• Between April 2003 and September 2008, researchers examined 3,768 non-dialysis participants in the Chronic Renal Insufficiency Cohort study.

• The Follow- up period was up to October 2018.

• There was a positive relationship between eGFR and 24-hour urinary calcium excretion.

• It has been reported that the variables most strongly correlated with 24-hour urinary calcium excretion were 24-hour urinary sodium (β=0.19 and 0.28 in males and females), serum parathyroid hormone (β=-0.22 and -0.20), loop diuretics (β=0.36 and 0.26), thiazide diuretics (β=-0.49 and -0.53), and self-identified black race (β=-0.23 and -0.27).

• The results demonstrated that the lower urinary calcium excretion was correlated with greater risks of outcomes, but these correlations were greatly attenuated or nullified after adjustment for baseline eGFR.