Schwartz A, Yogev Y, Zilberman A, et al. - In this prospective study, researchers investigated the presence of SARS‐CoV‐2 in the vaginal secretions of both reproductive‐aged and postmenopausal women during acute SARS‐CoV‐2 infection. From 35 women (aged 21‐93 years) who were diagnosed with acute SARS‐CoV‐2 infection by a nasopharyngeal RT‐PCR test, vaginal RT‐PCR swabs were obtained after a proper cleansing of the perineum. Among participants, 21 patients (60%) were in their reproductive years, of whom, 5 patients were in their third trimester of pregnancy. A positive vaginal RT‐PCR for SARS‐CoV‐2 was observed in two (5.7%) patients (one pre‐menopausal, and the other post‐menopausal woman). Both women had mild disease. These findings contradict most prior researches detecting no viral colonization in the vagina. Although neonates are exposed to the vaginal polymicrobial flora when passing through the birth canal, an acquisition of pathogens does not certainly mandate neonatal infection or clinical disease. Nevertheless, they emphasize to consider the possibility of vaginal colonization, when delivering a woman with acute SARS‐CoV‐2 infection.