Detection of pepsin in oral secretions of infants with and without laryngomalacia
Annals of Otology, Rhinology & Laryngology Feb 12, 2020
Klimara MJ, et al. - Given that laryngomalacia is a common cause of stridor in infants and is correlated with laryngopharyngeal reflux (LPR), researchers conducted pepsin, IL-1β, and IL-8 enzyme-linked immunosorbent assays to determine the presence of LPR. The sample consisted of children < 2 years old with laryngomalacia diagnosed by flexible laryngoscopy and children without stridor. They involved 16 laryngomalacia and 16 controls in this analysis. According to findings, pepsin in saliva seems to be linked to laryngomalacia, indicating a role for salivary pepsin as a noninvasive marker of LPR in patients with laryngomalacia.
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