Vasiliauskaitė I, Oellerich S, Ham L, et al. - Researchers conducted this retrospective, interventional case series to assess the 10-year graft survival and clinical outcomes of the first case series after Descemet membrane endothelial keratoplasty (DMEK). The following 100 consecutive primary DMEK eyes (88 patients) were involved after excluding the very first 25 DMEK eyes that constitute the technique learning curve. At 5 and 10 years after DMEK, 68 and 57 of 100 eyes were still available for analysis, respectively. Of those eyes, 82% and 89% reached a best-corrected visual acuity of ≥ 20/25 (Decimal VA ≥ 0.8) at 5- and 10 years postoperatively. Most of the eyes operated in the DMEK pioneering phase show excellent and consistent clinical outcomes with low postoperative complication rates and promising survival of the graft during the first decade following surgery. This indicates DMEK could be a safe option for long-term treatment of corneal endothelial diseases.