Basak SK, et al. - By performing this retrospective, noncomparative, interventional case series, researchers analyzed the clinical result as well as the postoperative course of Descemet membrane endothelial keratoplasty (DMEK) in irreversible corneal edema secondary to herpes simplex virus (HSV) endotheliitis. They examined 19 eyes of 19 patients who had standard DMEK combined with cataract surgery (triple DMEK). Perioperative oral acyclovir and prednisolone were administered to all patients. They found that a best spectacle-corrected visual acuity of 0.3 or better was achieved in 14 (73.7%) eyes following 1 year. At the last visit, a clear graft without any rejection episode was reported in 17 (89.5%) patients. A decrease in the mean pachymetry from 667.1 ± 62.1 to 512.8 ± 27.1 μm was noted following 3 months. According to the findings, DMEK in persistent corneal edema following HSV endotheliitis continues to be challenging but resulted in encouraging outcomes. HSV recurrence may complicate the postoperative course. The usefulness of prophylactic oral antivirals for 1 year or more and topical antivirals for recurrence prevention was suggested.