Scope A, Farnetani F, Haupt S, et al. - Given a risk of melanoma in correlation with nevus phenotype, researchers here investigated dermoscopic and clinical predictors of microscopic patterns of typical nevi. Using reflectance confocal microscopy (RCM), they assessed 310 nevi from 112 participants (mean age 44 years; 51 women). They observed most often association of dermoscopic reticular pattern (59.9%) with RCM ring pattern, dermoscopic globular with RCM composite (56.6%) and RCM clod (35.9%), dermoscopic complex with RCM composite (76.3%), and dermoscopic homogenous with RCM clod (50.8%). Improvement in the prediction of microscopic patterns, beyond dermoscopy alone, was noted in correlation with integrating dermoscopic pattern with contour, diameter, color, and anatomic location of nevi. The dermoscopic clinical regression model precisely classified lesions to RCM ring vs RCM clod in 90% and to RCM ring vs RCM composite patterns in 81%.