Gambadauro P, et al. - The researchers carried out a systematic review and meta-analysis to assess whether endometriosis correlates with depressive symptoms and whether the relationship is modulated by pelvic pain via a systematic search of PubMed, Embase, PsychINFO, and the Cochrane Library through September 2017. They found that patients with endometriosis who reported pelvic pain had significantly higher depression levels vs without pain. There was no significant difference between pelvic pain and endometriosis women and pelvic pain women but without endometriosis. Findings revealed that the association of endometriosis with depressive symptoms is largely determined by chronic pain, but can also be modulated by vulnerabilities in individual and context. Data reported that awareness of the complex association between endometriosis and depressive symptoms informs tailored care and patient-centred research results.