Liew TM - In this cohort study involving 13,462 candidates, researchers assessed the independent risks of neurocognitive disorders (NCD) correlated with depression and subjective cognitive decline (SCD), defined as a person’s subjective understanding of deteriorating cognition in the absence of objective cognitive deficits. The study sample consisted of candidates who were ≥ 50 years old with normal cognition at baseline. Findings suggested that both depression and SCD were independently linked to the risk of mild cognitive impairment and dementia, with an HR of 1.4 and 2.0, respectively. The findings may alter the clinical strategy for SCD management in depression, indicating that a greater emphasis on prodromal NCD detection in older patients with SCD depression is needed. They may also impact understanding of NCD, where commonalities and differences in depression and SCD neurobiological pathways needs to be described by further research.