Depression predicts cognitive and functional decline 1 month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study)
International Journal of Geriatric Psychiatry Oct 17, 2020
Oldham MA, Lin IH, Hawkins KA, et al. - Researchers examined if and how baseline depression and cognition are associated with the risk of decline in the Clinical Dementia Rating Sum‐of‐Boxes (CDR‐SB) 1-month post‐coronary artery bypass graft (CABG) surgery, a combined measure of cognition and function. They performed a prospective observational cohort study, including 148 patients undergoing CABG surgery. Of these patients, 124 (83.8%) completed 1‐month follow‐up assessment. After CABG surgery, CDR‐SB decline occurred in 14.5% individuals. In multivariate regression, older age and depression were significantly associated with 1‐month decline. CDR‐SB decline was also predicted by baseline performance on visual Wechsler memory scale (delayed), Hopkins verbal learning test (immediate and delayed), controlled oral word fluency test, and Trails B. In conclusion, CDR‐SB decline was seen in about one in seven patients 1 month after CABG surgery. Preoperative depression was identified as a predictor of CDR‐SB decline one month post‐CABG.
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