Grosso A, et al. - In an Italian multicenter, population-based, multicase-control study, researchers analyzed a representative sample of the Italian general population to examine the link between depression and asthma or rhinitis. They categorized 2,227 participants (age 21-86 years, female 50%) into a current asthma (n = 528) group, a rhinitis without asthma (n = 972) group, and controls (n = 727). In individuals with asthma, rhinitis and controls, the reported prevalence of depression was 16.7%, 11.9%, and 5.1%, respectively. Worse respiratory-health related quality of life and more frequent disease-related symptoms were found in relation to asthma and rhinitis with depression vs non-depressed counterparts. In adults from the general population, strong associations of rhinitis exacerbations, especially in non-atopic individuals, and low asthma control with the presence of depressed mood were evident in this study.