Kim D, et al. - Using the 2007-2016 National Health and Nutrition Examination Survey database among adults (20 years or older) in the United States, researchers conducted a cross-sectional analysis in a large population sample to determine if depression is correlated with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related advanced fibrosis. The Patient Health Questionnaire evaluated depression and functional impairment resulting from depression. A total of 10,484 individuals (mean age was 47.0 years) were analyzed. People with depression were more likely to be older, women, diabetic, hypertensive, and smokers vs those without depression. In addition, people with depression had a higher body mass index and waist circumference, higher levels of total cholesterol, triglyceride and fasting glucose and gamma-glutamyltransferase vs those without depression. Those with depression were 1.6-2.2-fold more likely to have NAFLD vs those without depression. Depression was independently linked to NAFLD in a nationally representative sample of US adults. Depression has not been associated with advanced fibrosis related to NAFLD.