Frolkis AD, Vallerand IA, Shaheen AA, et al. - Researchers conducted this investigation to evaluate the effect of depression and antidepressant therapies on the development of inflammatory bowel disease (IBD). To identify a cohort of patients with new-onset depression from 1986 to 2012, they used The Health Improvement Network. A total of 403,665 patients were identified with incident depression. Findings suggested that IBD was more likely to be diagnosed in patients with a history of depression. By contrast, for Crohn's disease and ulcerative colitis, antidepressant treatments were selectively protective.