Ghabrash MF, Bahremand A, Veilleux M, et al. - Researchers sought to determine if and how depression and main outcomes (opioid use and treatment retention) of methadone and buprenorphine treatment are associated among people with opioid use disorders (OUDs). Searching five electronic databases (MEDLINE, PubMed, Embase, Evidence-Based Medicine Reviews, and Cumulative Index of Nursing and Allied Health Literature Complete) from January 1970 to April 2019, they identified 12,296 records and retained 18 studies that met inclusion criteria. The evidence gained was of inconsistent nature prohibiting drawing of definitive conclusions, however, it was postulated that among OUDs patients, the presence of depression may not always prognosticate negative outcomes related to retention and drug use during the course of opioid agonist therapy. Especially, the hypothesis that fair treatment of depression can increase treatment retention is promising and is in support of the call for raised efforts to render integrated care for comorbid mental health disorders and addiction.