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Dengue during pregnancy and live birth outcomes: A cohort of linked data from Brazil

BMJ Open Jul 29, 2019

Paixão ES, et al. - Using routinely collected Brazilian data from 2006 to 2012, researchers carried out a population-based cohort study to examine how maternal dengue severity impacts live birth outcomes. For this investigation, 16,738,000 live births were included. The data presented in this work showed a doubling of the risk of preterm birth and low birth weight was related to dengue hemorrhagic fever during pregnancy and a 10%-20% increase in the risk of preterm birth and low birth weight, respectively, was seen in association with mild-dengue women. Medical interventions intended to mitigate the mother’s risk related to dengue hemorrhagic fever may be a contributing factor to adverse birth outcomes. Neither severe nor mild disease increased risk for small gestational age. During the acute disease phase, the link between dengue and birth outcomes was strongest within the first 10 days of the onset of disease.

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