Kendle AM, et al. - Using data from the 2002-2015 National Inpatient Sample, the largest publicly-available all-payer inpatient database in the US, researchers presented updated national approximations of the prevalence and trends of sepsis, sepsis-related in-hospital mortality, and factors related with in-hospital mortality in women with sepsis at delivery. This serial, cross-sectional analysis yielded more than 55 million delivery-associated hospitalizations. Criteria for sepsis were met by 13,129 of these women, matching a rate of 2.4 per 10,000 deliveries. Observations revealed an increase in the rates of delivery-associated sepsis, but with a reduction in case fatality. The greatest odds of sepsis-related in-hospital mortality were maternal age greater than 40 and non-private insurance. A 10-fold increased prevalence of most selected obstetric comorbidities was seen in women with sepsis vs those without. deliveries paid for by Medicare, deliveries to women aged 40 or older, and deliveries to non-Hispanic Black women were among the highest crude rates of sepsis (per 10,000).