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Delirium in older adults is associated with development of new dementia: A systematic review and meta‐analysis

International Journal of Geriatric Psychiatry Feb 13, 2021

Pereira JBV, Thein MZA, Nitchingham A, et al. - A systematic review and meta‐analysis was conducted to assess the literature on the relationship between delirium and dementia, and the odds of developing new dementia after having delirium were calculated. Researchers searched MEDLINE, EMBASE, and PsycINFO for English‐language articles assessing the incidence of new dementia in older adult (≥ 65) in patients with delirium vs inpatients without delirium. For the meta‐analysis, a random-effects model was applied, and the overall effect size was estimated by applying reported raw data of event counts. The risk of bias was evaluated by the Newcastle‐Ottawa Quality Assessment scale. Six observational studies were included, with follow‐up times ranging from 6 months to 5 years. There is a significant risk of subsequently developing dementia in older adult inpatients who develop delirium. Elderly inpatients who developed delirium had nearly twelve times the odds of subsequently developing new dementia vs non‐delirious patients, as seen in the pooled meta‐analysis. The included studies mainly analyzed post‐surgical patients. Future studies on medical and ICU cohorts are needed. Further trials should evaluate if delirium duration, severity, and subtype influence the risk of developing dementia.

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