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Delays in cardiopulmonary resuscitation, defibrillation, and epinephrine administration all decrease survival in in-hospital cardiac arrest

Anesthesiology Feb 17, 2019

Bircher NG, et al. - Researchers assessed the impact of delays in starting cardiopulmonary resuscitation (CPR) vs the time from CPR to defibrillation or epinephrine treatment on survival for in-hospital cardiac arrest. They analyzed witnessed, index cases of cardiac arrest from the Get With The Guidelines–Resuscitation Database occurring between 2000 and 2008 in 538 hospitals. Outcomes revealed lower survival in association with delays in the initiation of CPR and from CPR to defibrillation or epinephrine treatment. Times to start of CPR greater than 2 minutes were linked with a survival of 14.7% vs 17.1% if CPR began in 2 minutes or less; times from CPR to defibrillation or epinephrine treatment of 2 minutes or less were linked with a survival of 18.0%, vs 15.0% for 3 to 5  minutes, 12.8% for 6 to 8  minutes, and 13.7% for 9 to 11  minutes.

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