Gaudry S, Hajage D, Benichou N, et al. - By conducting this systematic review and individual patient data meta-analysis, researchers investigated if a strategy of delayed vs early renal replacement therapy (RRT) start impacts 28-day survival among critically ill adults encountering severe acute kidney injury. Randomised trials comparing delayed and early RRT start approaches in patients with severe acute kidney injury were identified from MEDLINE (via PubMed), Embase, and the Cochrane Central Register of Controlled Trials. Eligible trials were those that included critically ill patients aged 18 years or older experiencing acute kidney injury. Findings revealed that survival was not impacted by the timing of RRT start among critically ill patients with severe acute kidney injury in the absence of urgent indications for RRT. It was concluded that delaying RRT start, with close patient monitoring, might result in a decreased use of RRT, thereby saving health resources.