Talavera B, Gomez-Vicente B, Martínez-Galdámez M, et al. - This study was conducted to ascertain the prevalence and predictors of delayed neurological improvement after complete endovascular reperfusion in anterior circulation acute ischemic stroke (AIS). Between January 2018 and June 2019, researchers conducted a retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive anterior circulation AIS treated with endovascular thrombectomy (EVT) in tertiary stroke centers of the NORDICTUS (NORD-Spain Network for Research and Innovation in ICTUS) network. In this study, 1,381 had proximal anterior circulation occlusions, 803 (58%) of whom achieved a modified Thrombolysis in Cerebral Infarction 3 out of 1,565 patients with consecutive AIS treated with EVT. The results showed that one-quarter of patients with anterior circulation AIS who do not clinically improve within the first 24 hours after complete cerebral endovascular recanalization will achieve long-term functional independence, regardless of the poor early clinical course. The findings revealed that male gender, lower initial clinical severity, and use of intravenous thrombolysis before EVT predicted this clinical pattern.