Zeng P, Qian L, Lof J, et al. - Given that different acoustic features are shown by perfluoropropane droplets formulated from commercial microbubbles vs their parent microbubbles, most likely from enhanced endothelial permeability, and delayed echo-enhancement imaging (DEEI) similar to delayed enhancement magnetic resonance imaging (DE-MRI) may be allowed by this enhanced permeability, therefore, researchers investigated whether this would enable identification as well as quantification of myocardial scar. Participants were 15 pigs, in whom 90 minutes of left anterior descending ischemia was induced by either balloon (n=13) or thrombotic occlusion (n=2), and were assessed by DE-MRI at 2-24 days after occlusion. Using DE-MRI, the range of infarct size area was from 0 to 46% of total left ventricular area. A contrast defect identified by single pulse harmonic imaging showed a close correlation with the infarct area by DE-MRI. Infarct zone enhancement, as evident after harmonic subtraction of the fundamental non-linear imaging images, showed a close correlation with infarct size. Based on these findings, it is valid to utilize Intravenously Definity nanodroplets using DEEI techniques for the detection as well as quantification of infarct zone at the bedside.