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Defining subclinical myocardial dysfunction and implications for patients with diabetes mellitus and preserved ejection fraction

The American Journal of Cardiology Aug 04, 2019

Ng ACT, Bertini M, Ewe SH, et al. - Researchers determined if finding subclinical myocardial systolic dysfunction in people with diabetes has any clinical utility and if it offers incremental net benefit for these patients. They examined a cohort of 397 type 2 diabetic individuals. Retrospective evaluation of clinical and echocardiographic data of patients was done. Evaluation of left ventricular (LV) global longitudinal strain (GLS) on transthoracic echocardiography using speckle tracking imaging was also carried out. LV GLS > −17.0% as seen in 104 healthy volunteers from the community defined subclinical LV systolic dysfunction. Findings revealed an independent association of subclinical LV systolic dysfunction with all-cause mortality in diabetic patients. The general population had survival comparable to that experienced by people with diabetes without subclinical LV systolic dysfunction. In people with diabetes, the clinical utility of using LV GLS and detecting subclinical LV systolic dysfunction as well as their ability to provide incremental net clinical benefit was suggested in decision curve analyses.

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