Wang X, Cui X, Ding C, et al. - In mild cognitive impairment (MCI) and Alzheimer's disease (AD), researchers evaluated if there is abnormal cross‐frequency integration in patients' brains during disease progression in this retrospective study. There were 46 normal control (NC), 85 patients with MCI, and 31 patients with AD included. They established multilayer network models for NC, MCI, and AD, and the multilayer participation coefficient was applied to evaluate the variation in the interlayer relationship in the course of disease development. They assessed the relationship between multilayer network measures and cognitive function. There was a clear deficit in cross‐frequency integration and the hub nodes were preferentially damaged in the multilayer networks of patients. Furthermore, these vulnerable hubs are correlated with patients' cognitive scores.