Zeltsman M, Dozier J, Vaghjiani RG, et al. - A total of 793 patients who underwent lobectomy for pathological stage I-III non-small cell lung cancer (NSCLC) without induction therapy during two time periods, an early-time period (2009-2010: minimally invasive surgery {MIS}, n = 204; and thoracotomy, n = 182) and a late-period (2014-2015: MIS, n = 308; and thoracotomy, n = 99) were reviewed in order to examine the use of epidural analgesia (EA) and its influence on the postoperative short-term outcomes of patients with NSCLC who received a lobectomy by either MIS or thoracotomy. The use of MIS lobectomy rose during the late-time period vs the early-time period. In people who underwent MIS lobectomy, the use of EA significantly declined in the late-time period vs the early-time period. No variation in postoperative morbidity and mortality between the two time periods in both MIS and thoracotomy was seen. In the late-time period MIS group, the length of stay in the no EA group (n = 150) was shorter compared with that in the EA group (n = 158). No variation in morbidity and mortality between the EA and no EA groups were noticed. In conclusion, in this study cohort, the noted reduction in the use of EA with the rising rate of MIS lobectomy did not negatively impact postoperative short-term outcomes.