Shrestha MP, et al. – The trends in the Clostridium difficile–associated fatality rate, hospital length of stay and hospital charges were inspected, over the last decade. Over two fold decrease was reported in the in–hospital fatality related to Clostridium difficile infection, in the United States in the last decade despite increasing infection rates. Irrespective of decreasing length of stay, the hospital charges of Clostridium difficile infection appeared to be on the rise.