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Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

BMC Musculoskeletal Disorders May 04, 2020

Yu H, Liu P, Zuo W, et al. - In this research, the angiogenic and apoptotic activity of the bone microvascular endothelial cells (BMECs) were tested in glucocorticoid-induced osteonecrosis of the femoral head (ONFH). Researchers recruited a sum of 12 patients, six of whom were assigned to the ONFH group whereas the other six served as the control group. The ONFH group was consisted of individuals with glucocorticoid-induced ONFH while the control group had femoral neck fractures. They conducted cell proliferation, cell viability, tube formation assay, Transwell assay, TUNEL assay, and Western blot analysis. Results showed that BMECs obtained from the glucocorticoid-induced ONFH patients had reduced angiogenic and elevated apoptotic activities, which could describe the pathogenesis and progression of glucocorticoid-induced ONFH.

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