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Decrease in the number of microaneurysms in diabetic macular edema after anti-vascular endothelial growth factor therapy: Implications for indocyanine green angiography-guided detection of refractory microaneurysms

Graefe's Archive for Clinical and Experimental Ophthalmology Jan 24, 2020

Mori K, Yoshida S, Kobayashi Y, et al. - In eyes with diabetic macular edema (DME) following intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents, researchers conducted this retrospective study to assess changes in the numbers of microaneurysms (MAs) on fluorescein angiography (FA) and indocyanine green angiography (IA). Participants in the study were 16 patients (21 eyes) with DME. All individuals received an initial loading dose of three monthly anti-VEGF injections. Thereafter, they received a pro re nata regimen for at least 12 months of follow-up. In patients with DME, intravitreal injection of anti-VEGF agents decreased the numbers of MAs. The numbers of MAs observed by late-phase IA could be useful predictors of recurrence of DME.
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