Ji C, Zhou Q, Qiu Y, et al. - Given the uncertainty concerning the pathogenesis of somatic symptom disorder (SSD) and that catastrophizing is a common cognitive distortion in SSD, researchers herein tested their hypothesis that the network topological metrics of SSD should be altered, and should link with catastrophizing scales. They recruited 32 medication-naïve, first-episode SSD patients and 30 age, gender matched HCs and accessed the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Rating Scale (HAMA) and Cognitive Emotion Regulation Questionnaire (CERQ). Scanning of functional MRI was done and construction of brain functional networks was done based on 166 anatomically cerebrum regions from the automated anatomical labeling 3 (AAL3) template. In the SSD group, there was a significant negative correlation of HAMD total score with the connection between the left medial superior frontal gyrus and the left sgACC. CERQ catastrophizing score was noted to be significantly negatively linked with nodal global efficiency of left sgACC and with the FCs between the left sgACC and other 13 seed nodes. Overall catastrophizing could indicate the specific sgACC-centered dysfunction of brain network global efficiency of SSD. The left sgACC is suggested to be a potential future therapeutic target of dealing with catastrophizing, which is a core cognitive distortion of SSD.