Chu KM, Jones EM, Meeks JR, et al. - Since stroke remains one of the leading causes of disability and death in the United States, researchers analyzed the National Inpatient Sample from 2006 to 2015 to characterize 10‐year nationwide trends in the use of comfort care interventions (CCIs) among patients with ischemic stroke, especially acute thrombolytic therapy with intravenous tissue‐type plasminogen activator and endovascular thrombectomy. Theyn also described in‐hospital outcomes and costs. Using validated International Classification of Diseases, Ninth Revision (ICD‐9) codes, adult patients with ischemic stroke with or without thrombolytic therapy and CCIs were identified. Advanced age, female sex, the White race, non‐Medicare insurance, higher income, disease severity, comorbidity burden, and discharge from non‐northeastern teaching hospitals were independently linked to getting CCIs. Regardless of the type of acute care, CCI use has increased in patients with ischemic stroke, though significant disparities endure. Fixing the disparities gap and optimizing access, outcomes, and costs for CCIs in stroke patients are critical areas for future research.