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Cytomegalovirus infection in pediatric severe ulcerative colitis-A multicenter study from the Pediatric Inflammatory Bowel Disease Porto Group of European Society of Pediatric Gastroenterology, Hepatology, and Nutrition

The Pediatric Infectious Disease Journal Feb 20, 2018

Cohen S, et al. - Here, the researchers compared outcomes of children with acute severe ulcerative colitis (ASC) who were cytomegalovirus (CMV) positive or CMV negative. They found a higher prevalence of CMV positivity in pediatric ulcerative colitis patients who required colectomy within 12 months of hospitalization for ASC.

Methods

  • Data was collected from centers affiliated with the Pediatric Inflammatory Bowel Disease Porto Group of European Society of Pediatric Gastroenterology, Hepatology, and Nutrition.
  • Researchers performed a multicenter retrospective case-controlled study.
  • CMV-positive children hospitalized for ASC were included.
  • They compared these children's colectomy rate during hospitalization and up to 1 year thereafter, matched with CMV-negative controls.

Results

  • The researchers included 56 children (15 CMV positive and 41 CMV negative).
  • More CMV-positive patients, compared with CMV negative, were resistant to intravenous corticosteroids (93% and 56% respectively, P=0.009).
  • Ganciclovir was administered in 14 CMV-positive children (93%) [5/14 (36%) with 5 mg/kg and 9/14 (64%) with 10 mg/kg].
  • Three (20%) CMV-positive and 3 (7.8%) CMV-negative patients required colectomy (P=0.17) during hospitalization.
  • Five (33%) and 5 (13%) CMV-positive and CMV-negative patients required colectomy, respectively (P=0.049) by 12 months, the significance of which was not retained on multivariate analysis.

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