Guo Y, et al. - Researchers reviewed the medical records of children with confirmed cytomegalovirus (CMV) encephalitis hospitalized in the Children’s Hospital of Chongqing Medical University from 2002-2017 to assess the clinical features of immunocompetent children with CMV encephalitis. They identified 18 patients with a median age of 5.1 months. The earliest and most common neurological symptom was “seizures,” while most patients also had fever and poor feeding, while the most noticeable biochemical finding was elevated cerebrospinal fluid (CSF) protein. They recommend considering the possibility of CMV encephalitis in the immunocompetent child, especially younger than 6 months of age, in the unexplained presence of any of these symptoms. Clinical improvement with limited adverse drug reactions were noted with ganciclovir. A poor short-term prognosis is not certain for CMV encephalitis in the immunocompetent infant. For determining the etiology, they suggest CMV PCR assays on CSF as essential, and the response to treatment and the outcome could be evaluated via measurement of the CMV load in CSF and urine.