Gholami F, et al. - Researchers undertook a randomized, controlled trial to determine how measures of superficial femoral artery and neuropathic symptoms are influenced by exercise training in patients with diabetic peripheral neuropathy (DPN). They randomized 31 study participants with established DPN to either an experimental or control group. The experimental group performed exercise training (50% to 70% of heart rate reserve, 30–45 minutes, 3 sessions/week) over 12 weeks. The investigators noted a significant rise in the flow mediated dilation (FMD) percentage in the experimental group vs the control group. However, resting baseline diameter and intima media thickness were not significantly altered. The exercise intervention resulted in a significant improvement in fasting glucose concentrations, HbA1c levels, and Michigan Diabetic Neuropathy Score (MDNS). A significant correlation between the alterations in MDNS and FMD and also between MDNS and HbA1c was suggested by Pearson's correlation coefficient. Overall, the researchers’ findings were suggestive of the implication of metabolic and vascular factors in the development of DPN, and thus may hold considerable clinical significance.