Miodownik C, et al. - Among 38 patients with chronic schizophrenia, researchers tested the effectiveness of curcumin, a natural polyphenol with a range of pharmacological activities, including antioxidant and neuroprotective effects, as an add-on agent to regular antipsychotic medications. For this 24-week, double-blind, randomized, placebo-controlled study, participants were treated with either 3000 mg/d curcumin or placebo combined with antipsychotics from January 2015 to February 2017. According to findings, curcumin's promising results in the treatment of negative symptoms as an add-on to antipsychotics can open up a new and safe therapeutic option for schizophrenia management. In additional research, however, these findings should be replicated. There was no patient complaining about any adverse effect.