Thota RN, et al. – In this study involving individuals at high risk of developing type 2 diabetes (T2D), researchers assessed the impacts of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycemic control and blood lipid levels. A total of 64 study participants were allocated to either double placebo (PL), curcumin plus placebo matching for LCn-3PUFA (CC), LCn-3PUFA plus placebo matching for curcumin (FO), or curcumin plus LCn-3PUFA (CC-FO) for 12 weeks. The results of this 2 × 2 factorial, randomized, double-blinded, placebo-controlled study indicated that reduction in insulin resistance and triglyceride levels by curcumin and LCn-3PUFA may be attractive strategies for reducing the risk of developing T2D. However, this investigation failed to show complimentary benefits of curcumin and LCn-3PUFA on glycemic control.